PGX-TPMT StripAssay

Genetic Variants of Thiopurine Therapy

Thiopurine-based therapeutic drugs may accumulate to toxic levels in patients carrying genetic variants of the drug-metabolosing enzyme TPMT.

The PGX-TPMT StripAssay identifies the most frequent polymorphisms in the TPMT gene with therapeutic relevance.

Response to Thiopurine-Based Therapy

  • Thiopurines are widely used in the treatment of leukemias and autoimmune disorders, and as immunosuppressants after organ transplantation.
  • Thiopurine compounds are converted to therapeutically inactive metabolites by the enzyme thiopurine S-methyltransferase (TPMT) which exists in different isoforms.
  • Some TPMT isoforms have substantially reduced enzyme activity which leads to accumulation of higher thiopurine concentrations when receiving standard dosage. Myelosuppression, a toxic effect on the bone marrow, may thus occur.
  • Identification of a patient's individual TPMT isoform is crucial for avoiding toxic effects of thiopurines.


Cat. PGX-TPMT  PGX-TPMT StripAssay (20 Tests)

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