PGX-TPMT StripAssay

Print
Genetic Variants of Thiopurine Therapy
Description

Thiopurine-based therapeutic drugs may accumulate to toxic levels in patients carrying genetic variants of the drug-metabolosing enzyme TPMT.

The PGX-TPMT StripAssay identifies the most frequent polymorphisms in the TPMT gene with therapeutic relevance.

Response to Thiopurine-Based Therapy

  • Thiopurines are widely used in the treatment of leukemias and autoimmune disorders, and as immunosuppressants after organ transplantation.
  • Thiopurine compounds are converted to therapeutically inactive metabolites by the enzyme thiopurine S-methyltransferase (TPMT) which exists in different isoforms.
  • Some TPMT isoforms have substantially reduced enzyme activity which leads to accumulation of higher thiopurine concentrations when receiving standard dosage. Myelosuppression, a toxic effect on the bone marrow, may thus occur.
  • Identification of a patient's individual TPMT isoform is crucial for avoiding toxic effects of thiopurines.

 

Cat. PGX-TPMT  PGX-TPMT StripAssay (20 Tests)

Download Brochure

Download Pack Insert

 

Literature

Reviews

There are yet no reviews for this product.

Company

Policies

Social

Back To Top

Back To Top

Disclaimer: The demo content provided with this template is for demo purposes only. All content (C) the original authors.